| Ivermectin has traditionally been used as an antiparasitic, but it also has antiviral and anti-inflammatory actions. Importantly, ivermectin has anti-cancer actions, and it increases the expression of the p53 tumor suppressor gene’s pro-apoptotic pathway. Ivermectin helps the cancer cells reestablish the ability to detect that it is cancerous and thereby trigger an internal process of cancer cell suicide. Inside the Cancer Cell The p53 gene lives inside the cell. Understand that each cell has an internal immune system, held deep inside it, called the cytosolic immune system. This system includes the p53 tumor suppressing gene and about a half a dozen other pathways with strange sounding names and all of these, living inside the cell itself, monitor the cells’ health. Importantly, if a cell becomes cancerous, its inside ‘fixing program’ will kill it in a process of cellular suicide termed apoptosis. More about the p53 gene….. The gene p 53 regulates the death of our cells. When a cell is dysfunctional or aged, it’s supposed to deactivate and die and then the cell is removed. Cancer gets ahead by deactivating or mutating that P 53 gene, thus making that cell immortal. Elephants have extra copies [twenty] of the tumor suppressing gene p 53 and elephants don’t get cancer. Whales also have multiple copies of the P 53 gene and are protected against cancer as well. Most mammals, including the dog, have only one P 53 gene and the mutation of this gene is found in cancerous cells. Genomic data from more than 20,000 human patients have confirmed that the TP53 is the most commonly mutated gene in all human cancers. In wild animals, p53 variations contribute to environmental adaptation and cancer resistance. Article on p53 Gene in Humans and Wild Animals |
